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目的建立不同工艺消栓口服液发酵前后HPLC指纹图谱,观察其化学成分变化。方法采用HPLC法,对不同工艺消栓口服液进行指纹图谱研究,以共有峰峰面积作为指标,进行相似度分析、聚类分析,并对黄芪甲苷进行含量测定。结果 HPLC色谱图中有19个共有峰的,指纹图谱有明显差异,15批消栓口服液明显聚为2类,发酵后化学成分变化较大。结论消栓口服液发酵后,黄芪甲苷含量的升高以及芍药苷的生物转化,提示微生物发酵技术为中药的开发与利用提供了新的思路和方法。
OBJECTIVE To establish HPLC fingerprints of different kinds of traditional Chinese medicine XiaoXiao oral liquid before and after fermentation and observe the changes of its chemical composition. Methods The HPLC method was used to study the fingerprints of different kinds of oral liquid of XiaoXiao. The similarity peak area was used as index to carry out the similarity analysis and cluster analysis, and the content of astragaloside IV was determined. Results There were 19 common peaks in the HPLC chromatogram. There were significant differences in fingerprints between the two groups. 15 batches of Xiaozhuo oral liquid were obviously clustered into two groups, and the chemical composition changed greatly after fermentation. Conclusion The increase of astragaloside and the biotransformation of paeoniflorin after Xiaozhang oral liquid fermentation indicate that the microbial fermentation technology provides a new idea and method for the development and utilization of traditional Chinese medicine.