目的：评价消银解毒搽剂治疗头皮银屑病的临床疗效与安全性。方法将50例患者随机分为治疗组和对照组，治疗组使用消银解毒搽剂，对照组使用哈西奈德溶液。疗程均为4周。并在4周末、停药2周后复诊，评价各组的疗效和安全性。结果第4周疗程结束2组有效率分别为80.0%和68.0%，差异有统计学意义（P＜0.05）；停药2周后治疗组改善优于对照组，有效率分别为68.0%和36.0%，差异有统计学意义（P＜0.05）。治疗组患者未发生明显不良反应。第4周疗程结束及停药2周后瘙痒评分改善程度，治疗组均优于对照组，差异有统计学意义（P＜0.05）。结论消银解毒搽剂治疗头皮银屑病安全、有效，无明显不良反应，适用于将来临床应用。“,”Objective To evaluate the safety and beneift of a 4-week treatment with self-designed Xiaoyinjie-du liniment X on the scalp condition and on the quality of life of 50 patients with light-to-moderate scalp psoria-sis. Methods 50 patients with moderate-to-severe scalp psoriasis were randomized to either Halcinonide liniment (n=25) or Xiaoyinjiedu liniment X (n=25). The treatments were applied once daily on the scalp for 4 weeks. VAS (visual analogue score) score of pruritus for each patient were recorded at the end of treatment and after 2 weeks. Results In Halcinonide treatment group or Xiaoyinjiedu treatment group, the Scalp-modiifed PASI scores were signiifcantly improved than before. The Xiaoyinjiedu liniment X formulation showed higher efifcacy than Halci-nonide on the Scalp-modiifed PASI at the end of treatment (80.0%vs 68.0%, P<0.05), and a signiifcantly higher efifcacy after 2 weeks (68.0%vs 36.0%, P<0.05). The Xiaoyinjiedu liniment X used in this study was well tolerated. The degree of pruritus in patients of the 2 treatment groups was signiifcantly reduced, and VAS score of Xiaoyinjiedu treatment group decreased more signiifcantly than Halcinonide treatment group, at the end of treat-ment and 2 weeks later. Conclusion Treating scalp psoriasis with self-designed Xiaoyinjiedu liniment X has safe efifcacy, no signiifcant adverse reactions and complications, and is suitable for further clinical practice.