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目的 探讨单唾液酸四己糖神经节苷脂治疗新生儿颅内出血的临床疗效.方法 选择舟山市妇幼保健院2016年1月至2018年12月收治的新生儿颅内出血患儿142例为研究对象,采用随机数字表法分为观察组71例与对照组71例.对照组患儿采用常规治疗,观察组患儿在对照组基础上结合单唾液酸四己糖神经节苷脂治疗.两组疗程均为14 d.比较两组治疗疗效、肌张力恢复时间、反射恢复时间和意识恢复时间,治疗前后神经行为测定评分(NABA评分)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、基质金属蛋白酶-2(MMP-2)、金属蛋白酶组织抑制剂-1(TIMP-1)和神经元特异性烯醇化酶(NSE)水平变化.结果 观察组总有效率(92.96％)高于对照组(77.47％)(x2=6.762,P＜0.05);观察组肌张力恢复时间[(7.68±1.29)d]、反射恢复时间[(6.83±1.20)d]、意识恢复时间[(8.34±1.54)d]均短于对照组[(10.25±2.31)d、(9.17±1.86)d、(10.53±1.08)d](t=8.185、8.908、9.811,均P＜0.05);观察组治疗后NABA评分[(40.37±0.65)分]高于对照组[(37.16±0.93)分](t=23.838,P＜0.05);观察组治疗后血清TNF-α[(26.37±4.25) pg/L]、IL-1β[(16.74±3.24) ng/L]、MMP-2[(78.39±16.57) μg/L]、TIMP-1[(179.32±17.65) ng/mL]和NSE[(13.52±2.19)μg/L]均低于对照组[(53.21±7.39) pg/L、(28.93±5.64) ng/L、(97.42±12.63) μg/L、(238.63±28.42) ng/mL、(21.43±2.89) μg/L](t=26.529、15.792、7.696、14.938、18.381,均P＜0.05).结论 单唾液酸四己糖神经节苷脂对新生儿颅内出血疗效良好,可降低血清TNF-α、IL-1β、MMP-2、TIMP-1和NSE水平,改善患儿神经行为功能.“,”Objective To investigate the clinical effect of monosialotetrahexosyl ganglioside in the treatment of neonatal intracranial hemorrhage.Methods From January 2016 to December 2018,142 neonates with intracranial hemorrhage admitted to the Maternal and Child Health Hospital of Zhoushan were randomly divided into observation group (71 cases) and control group (71 cases) according to the digital table.The control group was treated with routine treatment,while the observation group was treated with ganglioside needle on the basis of the control group.Both two groups were treated for 14 days.The therapeutic effects,muscle tone recovery time,reflex recovery time and consciousness recovery time were compared.The changes of neurobehavioral assessment score (NABA score),TNF-αt,IL-1β,MMP-2,T IMP-1 and NSE levels before and after treatment were compared.Results The total effective rate of the observation group (92.96％) was higher than that of the control group (77.47％) (x2 =6.762,P ＜ 0.05).The recovery time of muscle tension,reflex and consciousness in the observation group [(7.68 ± 1.29) d,(6.83 ± 1.20) d and (8.34 ± 1.54) d] were shorter than those in the control group [(10.25 ± 2.31) d,(9.17 ±1.86) d and (10.53 ± 1.08) d] (t =8.185,8.908,9.811,all P ＜ 0.05).After treatment,the NABA score of the observation group [(40.37 ± 0.65) points] was higher than that of the control group [(37.16 ± 0.93) points] (t =23.838,P ＜ 0.05).The serum levels of TNF-α [(26.37 ± 4.25) pg/L],IL-1β [(16.74 ± 3.24) ng/L],MMP-2 [(78.39 ± 16.57)g/L],TIMP-1 [(179.32 ± 17.65) ng/mL] and NSE [(13.52 ± 2.19) g/L] in the observation group were lower than those in the control group [(53.21 ± 7.39) pg/L,(28.93 ± 5.64) ng/L,(97.42 ±12.63) g/L,(238.63 ± 28) ng/mL and (21.43 ± 2.89) μg/L] (t =26.529,15.792,7.696,14.938,1 8.381,all P ＜ 0.05).Conclusion Ganglioside has good therapeutic effect on neonatal intracranial hemorrhage.It can reduce the serum levels of TNF-α,IL-1β,MMP-2,TIMP-1 and NSE,and improve the neurobehavioral function of neonates.