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哺乳类妊娠时产生内源性胰岛素抗性。例如孕妇血浆胰岛素浓度虽高,糖耐量却降低到糖尿病的程度。随着胎儿生长成熟,母体血中雌激素和尿酮效价增加,同时致糖尿的应激也加强。鉴于肝产生葡萄糖的作用被扰乱,是糖尿病的重要特征。作者用雌鼠研究外源性雌二醇(E)和孕酮(P)对肝内葡萄糖产生和糖原生成的影响以及产生抗胰岛素的作用。128只雌大鼠分四组:分别注射E、P和E+P(对照为麻油)共21天;每组再分为禁食2小时和24小时者各半。糖的异生以静脉注射丙酮酸-3~(14)C或丙氨酸-全-~(14)C后30分钟内转变成糖的百分率来计量。同时测血
Endogenous insulin resistance occurs in mammals during pregnancy. For example, pregnant women with high plasma insulin concentrations, glucose tolerance is reduced to the extent of diabetes. As the fetus grows mature, maternal blood estrogen and urinary ketone titer increases, while stress caused by diabetes also strengthened. In view of the disturbed role of the liver in producing glucose, it is an important feature of diabetes. The authors studied the effects of exogenous estradiol (E) and progesterone (P) on intrahepatic glucose production and glycogen production, as well as insulin resistance. 128 female rats were divided into four groups: E, P and E + P (control sesame oil) were injected for 21 days; each group was further divided into 2 and 4 hours of fasting. The heterosexuality of the sugar is measured as the percentage of sugar converted into sugar within 30 minutes after intravenous administration of pyruvate-3 to (14) C or alanine-all- (14) C. Simultaneous blood test