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目的：研究川芎嗪治疗增生性瘢痕的机制．方法：对增生性瘢痕成纤维细胞进行体外培养，通过ＭＴＴ法检测成纤维细胞的增殖活性，用羟脯氨酸（ＨＰ）比色法测定细胞胶原合成含量．结果：ＭＴＴ法显示川芎嗪可抑制增生性瘢痕成纤维细胞的增殖活性，可以减少成纤维细胞的胶原合成并使细胞形态学发生改变．结论：川芎嗪可以抑制增生性瘢痕成纤维细胞的增殖及胶原合成．
4. Objective : To study the mechanism of ligustrazine in the treatment of hypertrophic scar. METHODS: Hypertrophic scar fibroblasts were cultured in vitro. The proliferation activity of fibroblasts was detected by MTT assay. Collagen synthesis was determined by hydroxyproline (HP) colorimetry. RESULTS: MTT assay showed that tetramethylpyrazine inhibited the proliferation of hypertrophic scar fibroblasts, reduced the collagen synthesis of fibroblasts, and altered cell morphology. Conclusion: Tetramethylpyrazine can inhibit proliferation and collagen synthesis of hypertrophic scar fibroblasts.