目的探讨原发性干燥综合征(PSS)患者血小板减少的发生情况及治疗效果。方法回顾分析85例PSS患者的临床资料。结果 41例血小板减少组(A组)口眼干燥的发生率低于44例无血小板减少组(B组),但脾肿大发生率高于后者(P<0.05);A组尿蛋白出现率、血小板分布宽度(PDW)、免疫球蛋白A(IgA)明显高于B组(P<0.05),血小板比容(PCT)低于B组(P<0.05)。A组38例经综合治疗有效,3例无效。结论伴血小板减少的PSS患者更易合并蛋白尿及IgA、PDW的升高、PCT的下降,且口眼干燥发生率低。 Objective To investigate the incidence and therapeutic effect of thrombocytopenia in patients with primary Sjogren’s Syndrome (PSS). Methods The clinical data of 85 patients with PSS were retrospectively analyzed. Results The incidence of dry mouth in 41 patients with thrombocytopenia (group A) was lower than that in 44 patients without thrombocytopenia (group B), but the incidence of splenomegaly was higher than that of the latter (P <0.05). Proteinuria in group A PDW, IgA were significantly higher in group B than those in group B (P <0.05). The platelet specific volume (PCT) was lower than that in group B (P <0.05). A group of 38 cases were treated effectively, 3 cases were ineffective. Conclusions Patients with thrombocytopenia are more likely to have combined proteinuria and elevated levels of IgA and PDW, with a decrease in PCT, and a low incidence of dry mouth.