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本文作者对文献介绍的大鼠在体小肠回流实验装置进行了改进,并用来研究黄芩甙的吸收情况和胆管结扎与不结扎对黄芩甙吸收的影响。胆管结扎与不结扎的药动学参数为:平均吸收半衰期分别是15.45h~(-1)、11.42h~(-1)。最终吸收程度依次是24.44%,31.58%。经方差分析两者无显著差异(F<5.3)。
The author of this article has improved the experimental apparatus for in vivo small intestinal reflux in rats and used it to study the absorption of jaundice and the effects of bile duct ligation and non-ligation on the absorption of jaundice. The pharmacokinetic parameters of bile duct ligation and non-ligation were: the average absorption half-lives were 15.45 h~(-1) and 11.42 h~(-1), respectively. The final absorption was 24.44% and 31.58%, respectively. There was no significant difference between the two groups by analysis of variance (F<5.3).