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从４个观察点筛选出ＡＬＴ正常、抗ＨＡＶ阴性、无禁忌症的４～１８岁易感者５０８名，进行了５个不同批号的甲型肝炎减毒活疫苗（Ｈ２株）人体接种观察。接种疫苗后３天内每日观察接种反应，所有接种者无局部及全身反应。１个月随访期间未见与肝炎有关的副反应。免后８～１２周抗体阳转率为８８．７％～９１．５％，ＧＭＴ为２．７３～４．８８％。３～５周ＨＡＶＩｇＭ阳转率为３．６％～１８．１％。收集了３２名志愿者的大便２０５份，用ＫＭＢ１７细胞分离，阳性９８份，分离率４７．８％。３２人中有３０人排毒，排毒率９３．８％。
A total of 508 susceptible individuals aged 4-18 years with normal ALT, anti-HAV negative and no contraindications were screened from 4 observation points. Human inoculation of 5 live attenuated Hepatitis A attenuated vaccine (H2 strain) was conducted. Vaccination was observed daily for 3 days after vaccination, and all vaccinates had no local and systemic reactions. No side effects associated with hepatitis were observed during 1 month follow-up. After 8 to 12 weeks of free antibody positive rate of 88.7% to 91.5%, GMT 2.73 ~ 4.88%. The positive rate of HAVIgM in 3 ~ 5 weeks was 3.6% ~ 18.1%. Totally 205 volunteers were collected stool, with KMB17 cells isolated, positive 98, the isolation rate of 47.8%. 30 of 32 people detoxified, detoxification rate of 93.8%.