Leber氏病是家族遗传性视神经萎缩,主要好发于男性。国内报告都为单纯性视神经损害,我们收治两个家族共8例:同时伴有其它神经损害,报告如下: 例1,张××,男,18岁,住院号831831,1983年4月6日入院,1983年5月26日出院,10年前发现四肢活动乏力,1年后双下肢出现肌萎缩并逐渐向上发展,以后全身出现肌萎缩,近5年来在讲话 Leber’s disease is familial hereditary optic atrophy, predominantly in men. Domestic reports are simple optic nerve damage, we treated a total of 8 patients in both families: accompanied by other neurological damage, the report is as follows: Case 1, Zhang × ×, male, 18 years old, hospital number 831831, April 6, 1983 Admitted to hospital, was discharged on May 26, 1983, 10 years ago, found limbs weakness, a year after the lower extremities appeared muscle atrophy and gradually upward, after the body appeared muscle atrophy, the past 5 years speech