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目的:探讨转化生长因子β1(TGF-β1)与慢性乙型肝炎病毒(HBV)相关性肝病尤其是肝纤维化发生的关系及临床意义。方法:酶联免疫吸附实验(ELISA)测定45例慢性乙肝患者(乙肝组)、39例肝硬化患者(肝硬化组)及30例健康者(对照组)血清中的TGF-β1的含量,并检测肝纤维化指标。结果:乙肝组和肝硬化组的血清TGF-β1水平高于对照组,且乙肝组血清TGF-β水平明显低于肝硬化组(P<0.05)。乙肝组和肝硬化组的肝纤维化指标IV型胶原(IV-C),层黏连蛋白(LN),透明质酸(HA)的浓度均明显高于对照组,且肝硬化组肝纤维化指标均高于乙肝组(P<0.05)。血清TGF-β1水平与肝纤维化指标均呈正相关(r=0.537、0.653、0.756,P<0.05)。结论:TGF-β1水平与乙肝患者肝纤维密切相关,降低TGF-β1的水平,可能是防治乙肝患者后期肝纤维化的一种新方法。
Objective: To investigate the relationship between transforming growth factor-β1 (TGF-β1) and chronic hepatitis B virus (HBV) -related liver diseases, especially liver fibrosis and its clinical significance. Methods: Serum levels of TGF-β1 in 45 patients with chronic hepatitis B (hepatitis B), 39 patients with cirrhosis (cirrhosis) and 30 healthy controls (control group) were measured by enzyme linked immunosorbent assay (ELISA) Detection of liver fibrosis indicators. Results: Serum levels of TGF-β1 in patients with hepatitis B and cirrhosis were significantly higher than those in controls. Serum levels of TGF-β in patients with hepatitis B were significantly lower than those in patients with cirrhosis (P <0.05). The levels of IV-C, LN and HA in hepatitis B and cirrhosis group were significantly higher than those in control group, and liver cirrhosis group had liver fibrosis Indicators were higher than hepatitis B group (P <0.05). Serum TGF-β1 levels and liver fibrosis indicators were positively correlated (r = 0.537,0.653,0.756, P <0.05). Conclusion: The level of TGF-β1 is closely related to liver fibrosis in patients with hepatitis B, and the decrease of TGF-β1 level may be a new method for prevention and treatment of post-hepatic fibrosis in patients with hepatitis B.