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本研究通过给新生缺氧缺血脑病（HIE）大鼠腹腔注射不同剂量的超氧化物歧化酶（SOD）、维生素E（VitE）加维生素C（VitC），观察这些药物对HIE大鼠脑组织脂质过氧化物（LPO）的影响：分别用于大剂量的SOD和VitE＋VitC治疗时，HIE大鼠脑内LPO水平与仅注射生理盐水组相比无明显下降甚至增加（SOD大剂量组）。当将SOD和VitE＋VitC剂量分别降低10倍和2倍时，HIE鼠脑LPO水平明显降低并接近正常组。表明适当剂量的SOD及VitE＋VitC可以通过降低脑内LPO水平而减轻由缺氧缺血所致的脑损伤。但当其剂量过大时反而有可能加重这一损伤。
In this study, neonatal hypoxic-ischemic encephalopathy (HIE) rats were intraperitoneally injected with different doses of superoxide dismutase (SOD), vitamin E (VitE) and vitamin C (VitC), observed that these drugs HIE rat brain tissue Effects of Lipid Peroxide (LPO): When used in high doses of SOD and VitE + VitC respectively, the levels of LPO in the brain of HIE rats were not significantly decreased or even increased (high-dose SOD group). When the doses of SOD and VitE + VitC were reduced by 10-fold and 2-fold respectively, the LPO level in the brain of HIE rats decreased significantly and approached to the normal group. The results showed that the appropriate dose of SOD and VitE + VitC can reduce brain damage caused by hypoxia and ischemia by decreasing the level of LPO in the brain. However, when the dose is too large, it may aggravate the injury.