霍乱弧菌O_1血清群的El Tor生物型于1996年侵入越南,并且成为地方性传染病。1990～1994年间,越南平均每年报道有3 240例霍乱病人,病死率约为1%。孟加拉国等地现场试验表明,口服霍乱死菌苗安全性好,且对霍乱高危人群有保护作用(保护率约50%)。但这些菌苗因其价格昂贵和仅对幼儿有效等原因而未被越南这一发展中国家所采用。作者对越南自己生产的、价廉的口服霍乱死菌苗进行了现场试验研究。 The El Tor biotype of V. cholera O_1 serogroup invaded Vietnam in 1996 and became endemic. Between 1990 and 1994, Vietnam reported an average of 3 240 cases of cholera each year, with a case fatality rate of about 1%. Field trials in Bangladesh and other places showed that oral vaccine against cholera was safe and safe to protect chillers at high risk (about 50% protection rate). However, these vaccines have not been adopted by the developing countries of Vietnam because of their high cost and effectiveness only for young children. The author conducted a field study of Vietnam’s own inexpensive oral vaccine against cholera.