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为寻找一种对子宫内膜作用小、治疗更年期综合征有效的,同时又可避免孕激素对血脂代谢不利影响的药物,本文研究了尼尔雌醇(4mg/d,口服)对绝经后妇女血脂和高密度脂蛋白—胆固醇及亚类的影响;同时测定了用药前后血清 FSH、LH、E_2及 T 水平。结果显示:尼尔雌醇可降低血清 TG 水平、升高 Tch、HDl-ch HDL_2-ch 水平;Tch/HDL-ch、Tch/HDL_2-ch 及 HDL_3-ch/HDL_2-ch 三个比值下降,HDL_3-ch 水平无明显变化;用药后血清 FSH、LH 水平下降,E_2及 T 水平未见明显变化。结论:尼尔雌醇有利于绝经后妇女防止动脉粥样硬化的发生和发展,并可使之紊乱的内分泌环境相对协调稳定。
In order to find a drug that has a small effect on the lining of the uterus and is effective in treating menopausal syndrome, and at the same time it can avoid the adverse effects of progesterone on blood lipid metabolism, this study investigated nilestriol (4 mg/d orally) in postmenopausal women. Effects of lipids and high-density lipoprotein-cholesterol and subclasses; serum levels of FSH, LH, E2, and T were measured before and after treatment. The results showed that nilestriol can reduce serum TG levels, increase Tch, HDl-ch HDL 2 -ch levels, and decrease the ratios of Tch/HDL-ch, Tch/HDL 2 -ch, and HDL_3-ch/HDL 2 -ch, and HDL_3 There was no significant change in the level of -ch; serum levels of FSH and LH decreased after treatment, and no significant changes in E2 and T levels were observed. Conclusion: Nilestriol is beneficial to postmenopausal women to prevent the occurrence and development of atherosclerosis, and make the disordered endocrine environment relatively stable and stable.