已阐明人及小鼠体内对抗原特异性无应答与缺乏释放IL-2的T细胞有关。推测严重的结核病人对PPD的无变应性(anergic)的原因可能是产生IL-2的细胞相对减少或对刺激因子存在耐受性或是效应T细胞对IL-2的无应答性之故。为阐明IL-2在其中的作用,作者在体外分析了46例活动性肺结核病人(分为两组各23人:急性肺结核病人组与抗药性肺结核病人组)及33例OT阳性的健康志愿者(对照组)的外周血淋巴细胞(PBL)对 It has been demonstrated that antigen-specific non-response in humans and mice is related to the lack of T cells that release IL-2. It is speculated that the cause of anergic PPD in severe tuberculosis may be due to a relative decrease in IL-2-producing cells or tolerance to stimuli or to a nonresponsiveness of effector T cells to IL-2 . To elucidate the role of IL-2, 46 patients with active pulmonary tuberculosis (23 patients in each of two groups: acute pulmonary TB and drug resistant TB) and 33 patients with OT-positive healthy volunteers were analyzed in vitro (Control group) of peripheral blood lymphocyte (PBL) pairs