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目的探究乳腺钼靶X线片联合肿瘤标志物诊断乳腺癌的价值。方法选取该院2011年12月-2016年6月手术或病理确诊乳腺癌患者60例作为试验组,并选择同期体检正常者60例作为对照组。均晨起抽血4 ml检测并对比两组血清肿瘤标志物的水平;比较两组各项单项指标检测的阳性率以及对比两组肿瘤标志物联合检测、肿瘤标志物联合乳腺钼靶X线片的差异。结果 (1)血清肿瘤标志物水平:试验组的骨桥蛋白(OPN)、糖类抗原153(CA153)、癌胚抗原(CEA)均高于对照组,差异均有统计学意义(t=3.55、3.17、4.72,均P<0.01)。(2)单项指标检测:试验组的OPN、CA153、CEA及乳腺钼靶X线片检测阳性率均高于对照组,差异均有统计学意义(χ~2=5.35、6.19、4.71、9.28,P<0.05或P<0.01)。(3)联合检测:肿瘤标志物联合检测及肿瘤标志物联合乳腺钼靶X线片检测阳性率均高于对照组,差异均有统计学意义(χ~2=8.26、7.23,均P<0.01)。结论肿瘤标志物联合乳腺钼靶X线片检测乳腺癌具有较高的阳性率,对乳腺癌的早期发现、早期诊断、早期处理具有重要意义。
Objective To explore the value of mammography combined with tumor markers in the diagnosis of breast cancer. Methods Sixty patients with breast cancer who were surgically or pathologically diagnosed from December 2011 to June 2016 in our hospital were selected as the experimental group and 60 normal subjects were selected as the control group. Blood samples were collected 4 ml early detection and comparison of serum tumor markers in both groups; the two groups were compared the positive rate of detection of each single index and tumor markers in both groups combined detection of tumor markers combined with mammography The difference. Results (1) The levels of serum tumor markers: OPN, CA153 and CEA in the experimental group were significantly higher than those in the control group (t = 3.55 , 3.17,4.72, all P <0.01). (2) Single index test: The positive rate of OPN, CA153, CEA and mammography in the test group were higher than that of the control group (χ ~ 2 = 5.35,6.19,4.71,9.28, P <0.05 or P <0.01). (3) Combined detection: The positive rate of joint detection of tumor markers and mammography combined with tumor markers in mammography was higher than that of the control group (χ ~ 2 = 8.26, 7.23, both P <0.01 ). Conclusion The combination of tumor markers and mammography in detecting breast cancer has a high positive rate, which is of great significance for the early detection, early diagnosis and early treatment of breast cancer.