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目的：探讨维生素D对高脂饲养兔主动脉瓣钙化及血清瘦素含量的影响。方法雄性新西兰大白兔36只，随机均分为四组：A组给予含0.1％胆固醇饮食＋维生素D ；B组给予0.1％胆固醇饮食，不加维生素D ；C组给予正常饮食＋维生素D ；D组给予正常饮食，不加维生素D。喂养16周后，心脏超声检测各组兔主动脉瓣跨瓣压差及左心室射血分数，并检测各组兔血胆固醇相关指标及血清瘦素含量。结果 A、B组兔主动脉瓣跨瓣压差、TC、TG、HDL-C、LDL-C、钙和血清瘦素含量均高于C、D组，而左心室射血分数低于C、D组（P＜0．05）；A组兔主动脉瓣跨瓣压差、血清瘦素含量亦高于B组，而左心室射血分数低于B组（P＜0．05）。结论维生素D可导致高脂饲养兔血清瘦素含量明显增高，有诱导主动脉瓣钙化的作用；但对正常饮食喂养兔，维生素D并无诱导主动脉瓣钙化作用。“,”Objective To study the effects of vitamin D (VD) on the aortic valve calcification and serum leptin in high-fat feeding rabbits .Methods Thirty-six New Zealand white rabbits were randomly and equally divided into four groups of A (0.1% cholesterol diet plus VD ) ,B (0.1%cholesterol diet without VD) ,C(normal diet plus VD) and D(normal diet without VD) .After feeding for 16 weeks ,serum leptin and cholesterol-related indicators were detected and the measurements of aortic valve pressure gradient and left ventricular ejection fraction (LVEF) were performed by cardiac uhrasonography .Results The aortic valve pressure gradient ,serum levels of TC ,TG ,HDL-C , LDL-C ,calcium and leptin were higher and LVEF was lower in groups of A and B than those in groups of C and D(P<0 .05) .The aortic valve pressure gradient and serum level of leptin were higher and LVEF was lower in group A than those in group B (P<0 .05) .Conclusion VD can lead to obviously increase of serum leptin and induce aortic valve calcification in rabbits with high-fat feeding , which does not induce aortic valve calcification in rabbits with normal diet .