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阿克拉霉素(Aclacinomycin—A,商品名:安乐霉素),是第二代新的蒽环类抗癌药,它是一个RNA多聚酶的抑制剂。国内尚未广泛应用。本文报告11例急性非淋巴细胞白血病采用阿克拉霉素、阿糖胞苷、强的松联合化疗,其结果表明:9例患者有效(有效率82%),其中6例获得完全缓解(CR55%),3例部分缓解(PR27%).3例对柔红霉素(DNR)、阿霉素(ADM)已产生耐药性复发者仍显效,我们初步认为,阿克拉霉素与DNR、ADM在一定程度上无交叉耐药性。本药的副作用能被患者所接受,胃肠道的食欲不振、恶心、呕吐症状以及对骨髓的抑制是其主要的副作用:脱发是很轻的:4例心电图有可逆性的ST—T改变,关于它对心脏的毒副作用,有待进一步观察。
Aclacinomycin-A (brand name: Ampicillin) is the second-generation anthracycline anti-cancer drug, which is an RNA polymerase inhibitor. Not yet widely used in China. In this paper, 11 cases of acute non-lymphocytic leukemia were treated with aclacinomycin, cytarabine and prednisone. The results showed that 9 patients were effective (effective rate 82%), of which 6 achieved complete remission (CR 55% ), And partial relief in 3 cases (PR27%). Three cases were still effective in patients with relapsed drug resistance due to daunorubicin (DNR) and adriamycin (ADM). We initially considered that aclacinomycin was associated with DNR, ADM To a certain extent, there is no cross-resistance. Side effects of this drug can be accepted by patients, gastrointestinal loss of appetite, nausea, vomiting and inhibition of bone marrow is its main side effects: hair loss is very light: 4 cases of ECG reversible ST-T changes, About its toxic side effects on the heart, pending further observation.