Addison氏病最常发生于和慢性淋巴细胞性肾上腺炎有关的自身免疫性疾患。据推测可能是某种破坏性过程导致了肾上腺的萎缩,但尚无证据表明抗体是肾上腺炎及临床综合征的原因。有时,Addi-son氏病是一种自身免疫性多腺体综合征的一部分。本文通过对一例Ⅰ型自身免疫性多腺体综合征病人的观察,提示在一些亚临床型甲低的病人存有阻断TSH起作用的抗体,进而提出在Addison氏病人中可能亦存在阻断ACTH刺激肾上腺皮质分泌的抗体。病例系一患念球菌内分泌病综合征的女 Addison’s disease most commonly occurs in autoimmune disorders associated with chronic lymphocytic adrenitis. It is speculated that a destructive process may have caused adrenal atrophy, but there is no evidence that antibodies are responsible for adrenitis and clinical syndrome. Addi-son’s disease is sometimes part of an autoimmune polyglandular syndrome. In this paper, a case of type I autoimmune polyglandular syndrome observed in patients with hypothyroidism in some subclinical patients with TSH blocking the presence of antibodies, and then proposed in Addison’s disease may also exist in the block ACTH stimulates adrenocortical secretion of antibodies. The case is a woman suffering from cryptococcal endocrine syndrome