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目的 系统评价加速康复外科(ERAS)方案与传统方案对肝切除术结局的影响.方法 检索万方数据库、维普数据库、中国知网数据库、PubMed、Embase及Cochrane Library数据库中关于比较ERAS方案与传统方案在肝切除术围手术期应用的临床随机对照试验(RCT).检索时限从建库至2016年1月.由2位研究者独立进行资料提取,采用Cochrane手册5.1.0对文献质量进行评价,用RevMan 5.3.0软件对提取的数据进行meta分析.结果 本研究共纳入了7项RCTs共844例病例,其中良性肿瘤35例,恶性肿瘤809例.实施ERAS方案者有415例,传统方案者有429例.与传统方案比较,ERAS方案能明显减少术后总并发症的发生[OR=0.59,95％CI(0.41,0.87),P=0.007],也能减少Dindo-Clavien Ⅰ级并发症的发生[OR=0.45,95％ CI (0.27,0.76),p=0.002],且能缩短住院时间[WMD=-2.66,95％ CI(-3.64,-1.69),P＜0.000 01]和肛门首次排气时间[WMD=-20.25,95％ CI(-32.08,-8.42),P=0.000 8],但是EARS方案和传统方案的Dindo-ClavienⅡ～Ⅳ级并发症发生率比较差异并无统计学意义[OR=0.93,95％ CI (0.53,1.63),p=0.80].结论 本研究的meta分析结果提示,ERAS方案在肝切除围手术期应用安全、有效,但仍需进一步研究以识别影响肝切除术后快速康复的重要因素.“,”Objective To systematically evaluate effects of enhanced recovery after surgery (ERAS) programme on clinical outcomes of liver resection during perioperative period.Methods The randomized controlled trials (RCTs) of comparing ERAS programme with traditional care programme in patients underwent liver resection were searched by Wanfang,VIP,CNKI,PubMed,Embase,and Cochrane Library databases from inception to January 2016.The quality of the included RCT was assessed independently according to the Cochrane handbook-version 5.1.0 by two reviewers.Meta-analysis was conducted for the eligible RCTs by using RevMan 5.3.0.Results Seven RCTs containing 844 patients were included in this meta-analysis.There were 35 cases of benign tumor,809 cases of malignant tumor.The ERAS programmes were performed in 415 patients,while the traditional care programmes were performed in 429 patients.Compared with the traditional care programme,the overall complications rate and the Dindo-Clavien grade Ⅰ complications rate were significantly lower [OR=0.59,95％ CI (0.41,0.87),P=0.007;OR=0.45,95％ CI (0.27,0.76),P=0.002],the hospital stay and the first anal exhaust time were significantly shorter [WMD=-2.66,95％ CI (-3.64,-1.69),P＜0.000 01;WMD=-20.25,95％ CI (-32.08,-8.42),P=0.000 8] in the ERAS programme,but there was no statistically significant difference of the Dindo-Clavien grade Ⅱ-iⅣ complications rate between these two groups [OR=0.93,95％ CI (0.53,1.63),P=0.80].Conclusions ERAS is a safe and effective programme in liver resection during perioperative period.Future studies should define active elements to optimize postoperative outcomes for liver resection.