近年来,随着不孕不育人数的增长,外源性化学物质的生殖毒理学逐渐成为目前毒理学研究的热点。动物实验表明,很多种类的药物都对雄性动物生殖系统有损伤作用,药物对人类造成的生殖毒性正在受到人们的关注。本文将从性行为、生育力、生殖器官、激素、酶、遗传物质等方面介绍药物的雄性生殖毒性的表现,并简述药物引起雄性生殖毒性的机制。 In recent years, as the number of infertility increases, reproductive toxicology of exogenous chemicals has gradually become the focus of current toxicology research. Animal experiments show that many kinds of drugs are damaging to the reproductive system of male animals, and the reproductive toxicity caused by drugs to humans is receiving much attention. This article will introduce the performance of male reproductive toxicity of drugs from the aspects of sexual behavior, fertility, reproductive organs, hormones, enzymes, genetic material and so on, and briefly describe the mechanism of drug causing male reproductive toxicity.