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Objective:To observe the efficacy of the inhalation of an aerosolized group A streptococcal(GAS) preparation in treating orthotopic lung cancer in mouse models and assess the feasibility,safety,and effectiveness of this administration mode for lung cancer.Methods:Lewis lung carcinoma(LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models.After the tumor-bearing models were successfully established,as confirmed by computed tomography,the mice were administered by inhalation with an aerosolized GAS preparation(GAS group) or aerosolized normal saline(control group).The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically;meanwhile,the survival and quality of life were compared between these two groups.Results:The aerosolized GAS preparation showed remarkably anti-tumor effect,causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice.Furthermore,mice in the GAS group had significantly better quality of life and longer survival than those in control group.Conclusions:The inhalation of aerosolized GAS preparation may be a feasible,safe and effective solution for lung cancer.
Objective: To observe the efficacy of the inhalation of an aerosolized group A streptococcal (GAS) preparation in treating orthotopic lung cancer in mouse models and assess the possibility, safety, and effectiveness of this administration mode for lung cancer.Methods: Lewis lung carcinoma ( )))))))))))))))))))))))))) Normal saline(control group).The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically;meanwhile,the survival and quality of life were comparative between these two groups.Results:The aerosolized GAS condition showed remarkably anti-tumor effect,causing The necrosis of the orthotopic lung cancer cells in tumor-bearing mice.Furthermore,mice in the GAS group had significantl y better quality of life and longer survival than those in control group.Conclusions:The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer.