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目的 对比中低剂量醛氢叶酸 (CF)与氟脲嘧啶 ( 5 Fu)联合化疗的近期疗效和毒副反应。同时比较PLF与ELF两方案的疗效和毒性反应。方法 随机采用不同剂量CF/5 Fu +顺铂 (DDP)或足叶乙甙 (VP16)联合化疗方案治疗恶性肿瘤 117例。结果 中、低剂量CF联合化疗有效率分别为 38.0 %和 44.7%(P >0 .0 5 ) ,两组主要毒性反应均以白细胞减少、恶心呕吐、口腔炎和脱发为主 ,均无显著性差异。PLF与ELF方案的有效率分别为 44.0 %和 31.8%(P >0 .0 5 ) ,毒副反应亦为骨髓抑制、恶心呕吐及口腔炎 ,其Ⅲ～Ⅳ级白细胞减少、血小板减少和口腔炎的发生率分别为 11.4%与 44.3%、0 .9%与 5 .6 %及 3.9%与 11.1%(P <0 .0 5 ) ,有统计学差异。结论 低剂量CF与 5 Fu +DDP联合化疗是治疗鼻咽癌和胃肠道癌比较安全、有效、经济的化疗方案。
Objective To compare the short-term efficacy and side effects of low and middle dose of combination of 5-fluorouracil and 5-fluorouracil with chemotherapy. At the same time compare the efficacy and toxicity of PLF and ELF two programs. Methods A total of 117 malignant tumors were treated with different doses of CF / 5 Fu + cisplatin (DDP) or etoposide (VP16) in combination with chemotherapy. Results, the low dose of CF combined with chemotherapy were 38.0% and 44.7% (P> 0.05), the main toxicity of the two groups were leukopenia, nausea and vomiting, stomatitis and hair loss were the main, no significant difference. The effective rates of PLF and ELF regimen were 44.0% and 31.8% respectively (P> 0.05). The adverse reactions were myelosuppression, nausea and vomiting and stomatitis. The grade Ⅲ-Ⅳ leukopenia, thrombocytopenia and stomatitis The incidence rates were 11.4% and 44.3%, 0.9% and 5.6%, 3.9% and 11.1% respectively (P <0.05), with statistical difference. Conclusion Low-dose CF combined with 5 Fu + DDP is a safe, effective and economical chemotherapy for nasopharyngeal carcinoma and gastrointestinal cancer.