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目的探讨淋巴结微转移对结直肠癌患者病理分期的影响。方法采用2008年3月至2013年10月间行手术切除的60例结直癌患者,对990枚淋巴结进行常规HE染色和CK20免疫组化微转移的检测,并对结果进行统计学分析。结果应用HE染色法淋巴结转移检出率27.2%(269/990),CK20免疫组化淋巴转移检测率为37.2%(368/990),两者比较有明显性差异(P<0.05)。99枚淋巴结检出有微转移,11例TNM分期提高,HE染色重新分期率为18.3%(11/60)。结论 CK20免疫组化的检测可以明显提高淋巴结转移的检出率,有助于更准确地进行结直肠癌的临床病理分期。
Objective To investigate the effect of lymph node micrometastasis on the pathological stage of colorectal cancer. Methods Sixty-six patients with colorectal cancer underwent surgical resection from March 2008 to October 2013, 990 lymph nodes were examined by routine HE staining and CK20 immunohistochemical micrometastasis, and the results were statistically analyzed. Results The detection rate of lymph node metastasis by HE staining was 27.2% (269/990). The detection rate of CK20 immunohistochemical lymphatic metastasis was 37.2% (368/990), with significant difference (P <0.05). 99 micrometastases were detected in lymph nodes, 11 TNM staging was improved, and the HE staging re-staging rate was 18.3% (11/60). Conclusion The immunohistochemical detection of CK20 can significantly improve the detection rate of lymph node metastasis and help to more accurately perform the clinical and pathological staging of colorectal cancer.