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胃癌单克隆抗体(McAb)3H11具有高阳性反应率、高选择性及高亲和力的特点.以~(131)I标记后注入荷胃癌裸鼠模型中,其瘤/肝比可达8.26±1.26,定位指数达6.08 ±1.51,ID%/g达11.00±2.62.该McAb与~(131)I偶联后可明显增强后者对肿瘤的杀伤效应及减低毒副反应.~(131)I标记的McAb 3H11静脉注入19例拟行手术的胃癌患者中,16例获阳性显像(84.2%).经胃镜引导注入癌旁粘膜下行胃癌放射免疫导向手术,判别胃壁肿瘤浸润的灵敏度、特异性及准确率分别为946%,967%及959%.判别淋巴结转移的上述指标分别为99.2%、97.7%及98.8%.
Gastric cancer monoclonal antibody (McAb) 3H11 has high positive reaction rate, high selectivity and high affinity. It is labeled with ~ (131) I and injected into a model of nude mice bearing gastric cancer. The tumor/liver ratio is up to 8.26±1.26. The localization index reached 6.08±1.51, and the ID%/g reached 11.00±2.62. The coupling of McAb with ~(131)I can significantly enhance the latter’s killing effect on tumors and reduce toxic side effects. ~(131)I labeled Among the 19 cases of gastric cancer patients undergoing McAb 3H11 intravenous injection, 16 cases were positively diagnosed (84.2%). The sensitivity, specificity, and accuracy of gastric cancer invasion were determined by gastroscope-guided injection of paracancerous mucosa into gastric cancer and radioimmunoguided surgery. The rates were 946%, 967%, and 95%, respectively. The above indexes for the detection of lymph node metastasis were 99.2%, 97.7%, and 98.8%, respectively.