Analyses of rare earth elements (REE) in gold-bearing quartz vein, granite and altered wall-rock (amphibolite) collected from Jiapigou gold belt in Southeast Jilin Province were conducted using inductively coupled plasma-mass-spectrometry (ICP-MS). The results in- dicated that the Jiapigou gold belt underwent two periods of gold mineralization: the earlier mineralization was related to the intrusion of Neoarchaean kaligranite, where the REE of earlier gold-bearing quartz veins and Neoarchaean kaligranites were typically featured by lower concentration and positive Eu anomaly; the later mineralization was related to the intrusion of the Yanshanian granite in Mesozoic, where the REE of later gold-bearing quartz veins and Yanshanian granites were typically featured by high concentration and negative Eu anomaly. However, the metallogenic mechanisms of the earlier and of the later gold mineralization periods were analogous, metallogenic materials were heterogenous with metallogenic fluids which mainly originated from magmatic hydrothermal fluids, mixed with metamorphic fluids; the metallogenic materials were mainly derived from the altered wall rock. Analyses of rare earth elements (REE) in gold-bearing quartz vein, granite and altered wall-rock (amphibolite) collected from Jiapigou gold belt in Southeast Jilin Province were conducted using inductively coupled plasma-mass-spectrometry (ICP-MS) results in dicated that the Jiapigou gold belt underwent two periods of gold mineralization: the earlier mineralization was related to the intrusion of Neoarchaean kaligranite, where the REE of earlier gold-bearing quartz veins and Neoarchaean kaligranites were typically featured by lower concentration and positive Eu anomaly; the later mineralization was related to the intrusion of the Yanshanian granite in Mesozoic, where the REE of later gold-bearing quartz veins and Yanshanian granites were typically featured by high concentration and negative Eu anomaly. However, the metallogenic mechanisms of the earlier and of the later gold mineralization periods were analogous, metallogenic materials were heterogenous with metallogenic fluids w hich mainly originated from magmatic hydrothermal fluids, mixed with metamorphic fluids; the metallogenic materials were mainly derived from the altered wall rock.