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采用溶剂铸膜法制备载羟考酮的黏膜黏附舌下膜。采用经校准的移液管将不同聚合物溶液滴至聚苯乙烯平板上,考察其铸膜性能。结果在受试的聚合物材料中,低、中分子量羟丙纤维素(HPC)和2种不同酯化度的果胶(PC)的铸膜性能较好,能制成适合黏膜应用的膜剂,因此被选用。所制备的舌下膜均具有良好的含量均匀度和稳定性;能快速释药,8 min时的溶出
Preparation of Oxycodone - Coated Sublingual Membrane by Solvent Casting. Different polymer solutions were dropped onto a polystyrene plate using a calibrated pipette to investigate its cast film properties. Results Among the tested polymeric materials, low and medium molecular weight hydroxypropyl cellulose (HPC) and two pectins (PC) with different degrees of esterification exhibited better casting properties and were able to be formulated into films suitable for mucosal applications , So be chosen. The prepared sublingual films have good content uniformity and stability; can be quickly released, dissolution at 8 min