肝癌是严重危害人们生命与健康的一种恶性肿瘤。基因治疗被认为是肿瘤治疗的第五种模式。本文针对肝癌的基因治疗现状做出如下综述。一、免疫基因治疗　肿瘤细胞没有表达特异性抗原或有抗原表达但缺乏免疫原性 ,以及肿瘤细胞表面缺乏ＭＨＣ抗原和 /或Ｂ7分子的表达。这些自身缺 Liver cancer is a malignant tumor that seriously affects people’s lives and health. Gene therapy is considered the fifth model of cancer treatment. This article reviews the current status of hepatocellular carcinoma gene therapy as outlined below. First, the immune gene therapy tumor cells did not express specific antigen or antigen expression but lack of immunogenicity, as well as the lack of tumor cell surface MHC antigen and / or B7 molecule expression. These are their own shortages