人铜锌超氧化物歧化酶(Cu/Zn Superoxide dismutase,SOD)是人体内超氧自由基(O·)的天然清除剂,实验证明,它对防止脂质过氧化、治疗冠心病、再灌流损伤(器育移植等)、关节炎及自家免疫等疾病有明显的疗效,是一个很有前途的活性多肽药物,因此,受到国内外研究者的高度重视。开展SOD的基因工程研究进而生产大量廉价的SOD产品具有重要的实用价值。本工作用化学法全合成了人铜锌SOD的基因,并在大肠杆菌中获得表达。 Human Cu, Zn Superoxide dismutase (SOD) is a natural scavenger of superoxide radical (O ·) in human body. It has been proved that it is effective in preventing lipid peroxidation, treating coronary heart disease, reperfusion Injury (transplant, etc.), arthritis and autoimmune diseases have a significant effect, is a promising active peptide drugs, therefore, by researchers at home and abroad attention. To carry out genetic engineering of SOD and thus produce a large number of cheap SOD products has important practical value. This work chemically synthesized human copper zinc SOD gene, and expressed in E. coli.