论文部分内容阅读
目的:本研究旨在评价非糖尿病患者急性心肌梗死成功再灌注后微量白蛋白尿对心功能的预后价值。方法:225例非糖尿病急性心肌梗死成功再灌注患者根据微量白蛋白尿是否阳性,分为微量白蛋白尿阳性组(n=124)和微量白蛋白尿阴性组(n=101)。观察两组患者再灌注治疗后24小时T波倒置和2小时ST段下降幅度;心肌梗死急性期、3个月和6个月时的左心室大小和左心室射血分数以及血浆脑钠肽的水平。结果:两组患者在年龄、性别、体重指数、吸烟、高血压史、心绞痛史、心肌梗死史、心律失常等方面差异均无统计学意义(P均>0.05)。再灌注后微量白蛋白尿阳性组24小时T波倒置及2小时ST段完全回落明显低于微量白蛋白尿阴性组(P<0.05);再灌注后微量白蛋白尿阳性组24小时T波无倒置和2小时ST段部分回落和无回落明显高于微量白蛋白尿阴性组(P<0.05),差异均有统计学意义。微量白蛋白尿阳性组与微量白蛋白尿阴性组比较,微量白蛋白尿阴性组6个月时左心室舒张末期容积高、左心室射血分数低(P均<0.05),差异均有统计学意义。3个月及6个月时血浆脑钠肽水平明显升高,微量白蛋白尿阳性组及微量白蛋白尿阴性组组内分别比较:心肌梗死急性期、3个月和6个月血浆脑钠肽呈下降趋势,差异均有统计学意义(P均<0.05)。结论:本研究结果提示,在非糖尿病急性心肌梗死成功再灌注患者中,微量白蛋白尿是心功能变化的预测指标。
PURPOSE: This study was designed to evaluate the prognostic value of microalbuminuria for cardiac function after successful reperfusion in non-diabetic patients with acute myocardial infarction. Methods: A total of 225 patients with successful reperfusion of non-diabetic acute myocardial infarction were divided into microalbuminuria positive group (n = 124) and microalbuminuria negative group (n = 101) based on whether microalbuminuria was positive. The T-wave inversion and ST-segment decrease at 2 hours were observed at 24 hours after reperfusion in both groups. Left ventricular ejection fraction and left ventricular ejection fraction at 3 and 6 months after acute myocardial infarction, plasma BNP Level. Results: There was no significant difference in age, sex, body mass index, smoking, history of hypertension, history of angina pectoris, history of myocardial infarction and arrhythmia between the two groups (all P> 0.05). The 24-hour T wave inversion and the 2-hour ST-segment regression of microalbuminuria-positive group after reperfusion were significantly lower than those of microalbuminuria-negative group (P <0.05). The 24-hour T wave of microalbuminuria positive group after reperfusion Inverted and 2-hour ST segment partial drop and no drop was significantly higher than the microalbuminuria negative group (P <0.05), the differences were statistically significant. Microalbuminuria positive group and microalbuminuria negative group, microalbuminuria negative group 6 months when the left ventricular end-diastolic volume, left ventricular ejection fraction low (P <0.05), the difference was statistically significant significance. Plasma BNP levels at 3 months and 6 months were significantly higher in patients with microalbuminuria and microalbuminuria than in patients with acute myocardial infarction, 3 months and 6 months Peptides showed a downward trend, the differences were statistically significant (P all <0.05). CONCLUSIONS: The results of this study suggest that microalbuminuria is a predictor of cardiac function in patients successfully reperfused with non-diabetic acute myocardial infarction.