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本研究对４２例骨髓增生异常综合征（ＭＤＳ）进行研究，采用骨髓细胞短期培养法，共１３例ＭＤＳ检出染色体异常核型，占３１％，ＭＤＳ－ＲＡＥＢ和ＲＡＥＢＴ（４１％）比ＭＤＳ－ＲＡ（２９％）异常核型检出率高（Ｐ＜０．０５），检出７种类型染色体异常核型，染色体数量异常８例，以三体８多见，染色体结构异常５例，均为平衡易位。ＭＤＳ－ＲＡ异常核型均为数量异常，ＭＤＳ－ＲＡＥＢ、ＲＡＥＢＴ则以结构异常为主。观察中发现２例具有核型异常的ＭＤＳ－ＲＡＥＢ转化为ＡＮＬＬ－Ｍ２和ＡＮＬＬ－Ｍ５，表明ＭＤＳ染色体核型与ＭＤＳ亚型、转归和预后密切相关。
In this study, 42 cases of myelodysplastic syndrome (MDS) were studied, using short-term culture of bone marrow cells, 13 cases of chromosomal abnormal karyotype detected by MDS, accounting for 31%, MDS-RAEB and RAEBT (41% The detection rate of abnormal karyotype of RA (29%) was high (P <0.05). Seven types of karyotypes were detected, including 8 cases of abnormal chromosome number, 8 cases of trisomy 8 and 5 cases of chromosomal abnormalities To balance the translocation. The number of abnormal karyotypes of MDS-RA were all abnormal, while the structural abnormalities were mainly found in MDS-RAEB and RAEBT. Two cases of MDS-RAEB with karyotypic abnormalities were found to be ANLL-M2 and ANLL-M5, indicating that the MDS karyotype is closely related to the subtype, prognosis and prognosis of MDS.