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作者对食盐摄取量7克/日没给降压药的原发性高血压住院病人,在空腹安静时腰穿采脑脊液数毫升,测定其血管紧张素(AT)Ⅰ、Ⅱ、去甲肾上腺素(NE)、加压素(ADH)、电解质浓度。并研究血压值与其他临床所见的关系。结果:原发性高血压(EH)病人脑脊液ATⅡ浓度比正常血压者(NT)呈现有意义的增高。脑脊液ATⅡ浓度与脑脊液采取时的血压值呈正相关(r=0.58,P<0,001),脑脊液与周围血之ATⅡ浓度及血浆肾素浓度(PRA)之间没有关系;慢性肾炎、肾性高血压及原发性醛固酮增多症等继发性高血压病人,脑脊液中的ATⅡ浓度比血压正常者呈现有意义的增高;脑脊液中的去甲肾上腺素浓度在脑血管障碍病人明显增高,与周围血NE浓度呈有意义的相关;
The author of the salt intake of 7 g / day did not give antihypertensive drugs in patients with essential hypertension, fasting and quiet in the lumbar puncture take a few milliliters of cerebrospinal fluid, measured angiotensin (AT) Ⅰ, Ⅱ, norepinephrine (NE), vasopressin (ADH), electrolyte concentration. And study the relationship between blood pressure and other clinical findings. Results: The concentration of AT Ⅱ in cerebrospinal fluid of patients with essential hypertension (EH) was significantly higher than that of normal blood pressure (NT). There was a positive correlation between ATⅡ concentration in cerebrospinal fluid and blood pressure in cerebrospinal fluid (r = 0.58, P <0,001). There was no relationship between ATⅡ concentration in cerebrospinal fluid and peripheral blood and plasma renin concentration (PRA). Chronic nephritis, renal hypertension and Primary hyperaldosteronism and other secondary hypertension in patients with cerebrospinal fluid AT Ⅱ concentration than normal blood pressure showed a significant increase in the cerebrospinal fluid concentration of norepinephrine in patients with cerebrovascular disease was significantly increased, and peripheral blood NE concentration Meaningful relevance