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目的探讨甲状腺显示胸腺样分化癌(CASTLE)的临床病理特征。方法对2例CASTLE进行组织形态学观察及免疫组化检测,并复习相关文献。结果 2例CASTLE均位于甲状腺下极,肿瘤呈推进式生长,肿瘤细胞梭形或多边形,排列成巢状或岛状,有纤维间隔,多形性不明显,核分裂少见。免疫组化:CD5、CD117和CEA(+)。结论 CASTLE是一种少见的甲状腺低度恶性肿瘤,有独特的组织学结构及免疫组化特点。
Objective To investigate the clinicopathological features of thyroid-like thyroid carcinoma (CASTLE). Methods Two cases of CASTLE histomorphological observation and immunohistochemistry, and review the relevant literature. Results Two cases of CASTLE were located in the lower pole of the thyroid gland. The tumor was propulsive growth. The tumor cells were spindled or polygonal, arranged in nests or islands with fibrous septa and irregular pleomorphism. Immunohistochemistry: CD5, CD117 and CEA (+). Conclusion CASTLE is a rare low-grade thyroid tumor with unique histological structure and immunohistochemical characteristics.