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目的评价依达拉奉注射液治疗急性脑出血的疗效和安全性。方法对40例符合条件的脑出血患者,随机分为治疗组和对照组,每组20例。两组均常规使用生理盐水250ml加20ml复方丹参注射液静脉滴注,1次/d,治疗组加用依达拉奉注射液30mg静脉滴注,1次/d,使用疗程为14d。结果 14d后两组分别进行临床疗效与ESS评定,治疗组总有效率达到89.1%,显效率为62.1%,而对照组分别为51.2%和39.4%,两组比较差异有显著性(P<0.01和P<0.05)。14d后ESS评分治疗组明显优于对照组(P<0.01)。结论依达拉奉注射液治疗急性脑出血具有疗效确切、安全性高的优点。依达拉奉通过消除自由基而抑制细胞膜脂质的过氧化和脑细胞(血管内皮细胞、神经细胞)氧化产生的障碍。对急性脑出血患者的脑血管起到脑保护的作用。
Objective To evaluate the efficacy and safety of edaravone injection in the treatment of acute cerebral hemorrhage. Methods Forty patients with ICH were randomly divided into treatment group and control group, with 20 cases in each group. Both groups were routinely used saline 250ml plus 20ml compound Danshen injection intravenously, 1 / d, the treatment group with edaravone injection 30mg intravenous infusion, 1 / d, the use of treatment for 14d. Results After 14 days, the clinical efficacy and ESS were evaluated in both groups. The total effective rate was 89.1% and the effective rate was 62.1% in the two groups, with 51.2% and 39.4% in the control group, respectively (P <0.01 And P <0.05). ESS score 14d after treatment group was significantly better than the control group (P <0.01). Conclusion Edaravone injection in the treatment of acute intracerebral hemorrhage has the advantages of definite curative effect and high safety. Edaravone inhibits lipid peroxidation of the cell membrane and inhibition of oxidation of brain cells (vascular endothelial cells, nerve cells) by eliminating free radicals. Acute cerebral hemorrhage in patients with cerebral vascular protective effect.