【摘 要】
：
The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps starting from commercially availa
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia M
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps starting from commercially available methyl gallate and veratraldehyde. The cytotoxicity of the intermediates was tested against HCT-8, BEL-7402, KETR3, HELA, BGC-823, KB and MCF-7 cell lines by the MTT test, and compound 15 exhibited significant cytotoxicity in HELA and KB cell lines.
The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps from commercially available methyl gallate and veratraldehyde. The cytotoxicity of the intermediates was tested against HCT-8, BEL-7402, KETR3, HELA, BGC -823, KB and MCF-7 cell lines by the MTT test, and compound 15 showed significant cytotoxicity in HELA and KB cell lines.
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