论文部分内容阅读
[目的]观察清热更年方对更年期综合征动物的影响。[方法]选用雌性SD大鼠,采用摘除卵巢方法更年期综合征动物模型,给药30d后测定血清性激素水平和子宫、肾上腺、垂体指数,同时观察药物对去势大鼠子宫、肾上腺、垂体组织病理学的影响。结果:清热更年方可升高去势大鼠血清中E2水平(P﹤0.01),有升高P、降低LH、FSH水平的趋势,有增加去势大鼠子宫、肾上腺指数的趋势,可以改善去势大鼠子宫、肾上腺、垂体的病理改变。[结论]清热更年方对更年期综合征有治疗作用,其作用机制可能与调节性激素水平有关。
[Objective] To observe the effect of Qingrenshiennian prescription on climacteric syndrome animals. [Methods] Female Sprague-Dawley rats were selected and ovariectomized climacteric syndrome animal model was adopted. Serum sex hormone levels and uterine, adrenal and pituitary indices were measured 30 d after administration. The effects of drugs on the uterus, adrenal and pituitary tissues in ovariectomized rats Influence of Neo-Confucianism. Results: The heat-clearing senility could increase E2 level in the serum of ovariectomized rats (P <0.01), the tendency of increasing P, decreasing the level of LH and FSH, increasing the tendency of uterus and adrenal index in ovariectomized rats, To improve the castration rat uterus, adrenal, pituitary pathological changes. [Conclusion] Qingre Gengnian Fang has a therapeutic effect on climacteric syndrome and its mechanism may be related to the regulation of sex hormones.