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通过对2株乙酰胆碱受体(AChR)自身抗体分子结构以及与致病性关系的分析,探讨了重症肌无力(MG)的发病机理。这2株抗体均为抗AChR上主要免疫原区(MIR)抗体,二者重链核苷酸同源性为99.7%,轻链同源性只有64.8%,说明重链在与AChRMIR结合上起重要作用。这2株抗体均未能在健康大鼠体内诱导出MG。通过与致病性AChR抗体可变区基因序列比较发现,这2株抗体的分子结构尤其是互补决定区(CDR)的氨基酸组成与致病性AChR抗体不同,表明抗AChRMIR抗体并不都具有致病性。
The pathogenesis of myasthenia gravis (MG) was explored by analyzing the molecular structure of two AChR autoantibodies and their relationship with pathogenicity. These two antibodies are the major anti-AChR immunogen region (MIR) antibodies, the two heavy chain nucleotide homology was 99.7%, light chain homology was only 64.8%, indicating that heavy chain in combination with AChRMIR Important role. None of these two antibodies induced MG in healthy rats. The amino acid composition of the molecular structures of these two antibodies, especially the complementarity determining regions (CDRs), was different from that of the pathogenic AChR antibody by comparison with the sequence of the variable region of the pathogenic AChR antibody, indicating that not all of the anti-AChRMIR antibodies have a Sick.