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目的 p5 3基因是与多种肿瘤发生、发展密切相关的抑癌基因 ,其单核苷酸多态性与肺癌的早期诊断和放射治疗疗效密切相关。检测p5 3基因多态性将对肺癌患者的放疗疗效及预后提供指导意义。本文简要综述p5 3基因单核苷酸多肽性与肺癌及与其组织学类型和种族的关系。
Objective The p5 3 gene is a tumor suppressor gene closely related to the occurrence and development of many tumors. The single nucleotide polymorphism is closely related to the early diagnosis and radiation therapy of lung cancer. Detection of p5 3 gene polymorphism in patients with lung cancer radiotherapy efficacy and prognosis to provide guidance. This article briefly reviews the association of the single nucleotide polymorphisms of the p5 3 gene with lung cancer and its histological type and ethnicity.