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目的探讨宫颈病变患者配偶人乳头瘤病毒感染的相关性,为宫颈病变的预防提供依据。方法对有宫颈病变且高危型HPV感染的阳性患者56例及健康女性38例(其配偶分别为研究组56例和对照组38例),采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术对其男性配偶的阴部进行HPV检测。结果研究组HPV检查阳性率37.50%,明显高于正常对照组13.16%(P<0.05)。研究组21例HPV阳性者中夫妇双方有相同HPV亚型感染者11例(52.38%)。其中58型占首位。结论宫颈病变患者配偶HPV感染明显高于正常人群,部分配偶感染相同HPV亚型,故对其配偶进行HPV检测和健康教育有利于宫颈病变的预防。
Objective To investigate the correlation between spouse HPV infection in patients with cervical lesions and provide evidence for the prevention of cervical lesions. Methods 56 patients with cervical lesions and high-risk HPV infection and 38 healthy women (spouses were study group 56 cases and control group 38 cases) were amplified by PCR in vitro and DNA reverse hybridization DNA chip technology HPV testing of the genitals of their male spouses. Results The positive rate of HPV test in study group was 37.50%, which was significantly higher than that in control group (13.16%, P <0.05). In the 21 cases of HPV-positive study group, 11 cases (52.38%) had the same HPV subtype infection in both sides. Of which 58 accounted for the first place. Conclusion The spouse HPV infection of patients with cervical lesions is significantly higher than that of the normal population. Some spouses are infected with the same HPV subtype. Therefore, HPV testing and health education of their spouses are helpful for the prevention of cervical lesions.