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对三株人肺癌裸小鼠移植瘤模型作形态学跟踪观察结果显示:人肺燕麦细胞癌连续传代4年后,瘤内小区有柱形细胞;神经性分泌颗粒明显减少;局部呈现腺型分化的倾向。人肺鳞状细胞癌连续传代3年后,上皮大部分分层清楚;张力纤维束分布广泛;核仁微分离典型;分化程度有升级趋势。人肺腺癌连续传代至今已逾4年,微小腺腔作为判别低分化腺癌的特异性结构仍比较原始,形态学无明显改变,但移植瘤从59代起出现淋巴结和肺内转移灶。
The results of morphological follow-up of three human lung cancer xenograft models showed that after 4 years of continuous passage of human Oat cell carcinoma, there were columnar cells in the tumor area; neurological secretory granules were significantly reduced; local glandular differentiation was observed. Propensity. After 3 years of continuous passage of human lung squamous cell carcinoma, most of the epithelium were clearly stratified; the tension fiber bundles were widely distributed; the nucleolus were micro-dissected; the differentiation degree was upgraded. It has been more than 4 years since the continuous passage of human lung adenocarcinoma. The specific structure of the small glandular cavity as a differential diagnosis of poorly differentiated adenocarcinoma is still relatively primitive, and there is no obvious change in morphology. However, the transplanted tumor has metastasized to lymph nodes and lung in the 59th generation.