单克隆抗体CEA(癌胚抗原)是过去研究最多的肿瘤相关抗原之一,许多报道表明CEA 是一组同种抗原,抗CEA 抗体对它有显著不同反应性。抗CEA 单克隆抗体(MoAb)能与CEA 分子上各个表位发生反应,其中一些对结肠癌有高度反应性,并与肿瘤表面结合。Koprowoski 等在1979年报道了一种称之谓19-9的MoAb,它能与一种组织碳水化合物抗原决定簇(CA19-9)发生反应。在正常胃和肠粘膜,胰,正常脾,红细胞,黑色素瘤 The monoclonal antibody CEA (Carcinoembryonic Antigen) is one of the most studied tumor-associated antigens in the past. Many reports indicate that CEA is a group of allogeneic antigens and that anti-CEA antibodies are significantly differently reactive. Anti-CEA monoclonal antibodies (MoAbs) react with various epitopes on the CEA molecule, some of which are highly reactive with colon cancer and bind to the tumor surface. Koprowoski et al. reported in 1979 a MoAb called 19-9, which reacts with a tissue carbohydrate epitope (CA19-9). In normal stomach and intestinal mucosa, pancreas, normal spleen, red blood cells, melanoma