目的探讨Ａ型肉毒毒素治疗眼睑及面肌痉挛的疗效。方法应用国产Ａ型肉毒毒素局部注射治疗特发性眼睑痉挛４９例，伴有面肌痉挛者１０例。结果所有病例经治疗均取得效果。在二年９个月内经随访者复发率达６５．４％。复发再注射均有效。结论为何提高疗效，减少复发是一个值得研究的问题。由于该疗法操作简单行之有效，值得临床应用，但应慎重，必须随访。 Objective To investigate the efficacy of botulinum toxin A in the treatment of eyelid and hemifacial spasm. Methods 49 patients with idiopathic blepharospasm were treated with local injection of botulinum toxin type A, and 10 patients with hemifacial spasm. Results All cases were treated to achieve the desired result. The recurrence rate was 65.4% in follow-up within two years and nine months. Recurrence and injection are effective. Conclusions Why improve the curative effect and reduce the relapse is a worthy research question. As the simple and effective operation of the therapy, it is worth clinical application, but should be cautious and must be followed up.