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目的:探讨多巴胺加多巴酚丁胺对新生儿硬肿症伴多器官功能衰竭(MSOF)的疗效。方法:将使用该药治疗的30例作为治疗组,未用该药的28例作为对照组,观察两组患儿的病死率、病情好转时间和住院时间。结果:治疗组较对照组病死率无显著差异(P>0.05),但能明显缩短主要症状、体征的恢复时间、MSOF纠正时间和住院时间(P<0.01)。结论:多巴胺加多巴酚丁胺治疗新生儿硬肿症伴MSOF疗效确切,其机制可能和改善微循环、增加组织灌注有关。
Objective: To investigate the effect of dopamine and dobutamine on neonatal sclerema with multiple organ failure (MSOF). Methods: Thirty patients treated with this medicine were used as the treatment group and 28 cases were not used as the control group. The mortality, the improvement time and hospital stay of the two groups were observed. Results: There was no significant difference in the mortality rate between the treatment group and the control group (P> 0.05), but significantly shortened the recovery time of major symptoms, signs, MSOF correction time and hospital stay (P <0.01). Conclusion: Dopamine plus dobutamine is effective in treating neonatal sclerema with MSOF. The mechanism may be related to improving microcirculation and increasing tissue perfusion.