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目的:分析急性白血病(AL)免疫表型特点及其临床意义。方法:采用单克隆抗体直接免疫荧光标记法的流式细胞术,对71例AL进行免疫表型检测。结果:71例AL患者以系列专一型表达为主,同时亦存在抗原交叉表达、不表达特异性抗原及混合型等情况。AL患者CD34和HLA蛳DR表达分别占56.3 %和61.9 %,M3患者均不表达HLA蛳DR。My+ALL患者完全缓解(CR)率(60.0 %)低于My - ALL患者CR率(80.6 %),两组相比有显著性差异(P<0.05)。CD+34 ALL与CD蛳34 ALL患者缓解率基本相同;CD+34 AML患者CR率(58.3 %)明显低于CD蛳34 AML患者CR率(88.9 %),两组相比有显著性差异(P<0.05)。结论:白血病免疫表型检测结合FAB分型可以提高诊断的准确率,部分免疫表型特征对判断预后有一定的意义。
Objective: To analyze the immunophenotype of acute leukemia (AL) and its clinical significance. Methods: Immunocytochemistry was performed on 71 cases of AL using flow cytometry with monoclonal antibody direct immunofluorescence labeling. Results: 71 patients with AL were mainly expressed in a series of specific types, and there were also cross-expression of antigens, non-specific antigens and mixed type. AL patients with CD34 and HLA 蛳 DR expression accounted for 56.3% and 61.9%, M3 patients did not express HLA 蛳 DR. The complete remission (CR) rate (60.0%) in patients with My + ALL was lower than that in patients with My - ALL (80.6%). There was significant difference between the two groups (P <0.05). The response rates of CD + 34 ALL and CD34 ALL patients were basically the same. The CR rate of CD34 + AML patients (58.3%) was significantly lower than that of CD3434ML patients (88.9%). There was significant difference between the two groups P <0.05). Conclusion: Leukemia immunophenotyping combined with FAB typing can improve the accuracy of diagnosis. Some of the immunophenotypic characteristics have certain significance in judging the prognosis.