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目的对2型糖尿病(type 2diabetes mellitus,T2DM)患者轻度认知功能障碍(mild cognitive impairment,MCI)的特点及危险因素进行分析。方法根据蒙特利尔量表(MoCA)评分将自2012年8月-2015年2月本院96例T2DM患者分为合并MCI者40例(观察组)和认知功能正常者56例(对照组),比较两组患者MoCA量表各项功能得分差异,并分析T2DM合并MCI的危险因素,性别、年龄、是否合并高血压、病程、吸烟史、受教育程度、体质量指数(BMI)及超敏C反应蛋白(hs-CRP)、糖化血红蛋白(HbAlc)水平。结果观察组在定向力、延迟回忆、视觉空间执行能力、语言功能、注意力等明显低于对照组(P<0.05);单因素分析显示,两组年龄、吸烟史、受教育程度、病程、超敏C反应蛋白(hs-CRP)、糖化血红蛋白(HbAlc)水平等因素差异有统计学意义(P<0.05)。多因素回归分析显示,年龄、病程、受教育程度、hs-CRP和HbAlc水平是T2DM合并MCI的独立危险因素。结论 T2DM合并MCI患者的认知功能多项受损,T2DM患者MCI的发生与年龄、病程、受教育程度、hs-CRP和HbAlc水平密切相关。
Objective To analyze the characteristics and risk factors of mild cognitive impairment (MCI) in type 2 diabetes mellitus (T2DM). Methods According to the Montreal Scale (MoCA), 96 patients with T2DM from March 2012 to February 2015 were divided into control group (n = 40) and control group (n = 40) The differences of scores of MoCA scale between the two groups were compared. Risk factors of T2DM with MCI, gender, age, hypertension, duration of disease, smoking history, education level, body mass index (BMI) and hypersensitivity C Reactive protein (hs-CRP), glycated hemoglobin (HbAlc) levels. Results The observation group was significantly lower than the control group in orientation ability, delayed recall, visual spatial executive ability, language function, attentiveness and so on (P <0.05). Univariate analysis showed that age, smoking history, education level, There were significant differences in hs-CRP, HbAlc levels between the two groups (P <0.05). Multivariate regression analysis showed that age, disease course, educational level, hs-CRP and HbAlc levels were independent risk factors for T2DM with MCI. Conclusion The cognitive function of T2DM patients with MCI is impaired. The incidence of MCI in T2DM patients is closely related to the age, course of disease, education level, hs-CRP and HbAlc levels.