目的　探讨1 31 Ⅰ治疗Graves病时 ,不同的剂量计算方法与治愈率以及治疗后并发症的关系。方法　在计算治疗Graves病所需1 31 Ⅰ时 ,分别采取不同的两种计算方法 ,观察两者治愈率及并发症的发生情况 ,并做多因素对比分析。结果　治疗组较对照组 1次治愈率提高约 12 % ,近期甲状腺功能减退延续为永久性甲状腺功能减退者亦明显减少 ,治疗效果明显优于后者。结论　1 31 Ⅰ治疗剂量计算时 ,既要有公式的规范性 ,又要有根据具体情况调节的灵活性 ,即可明显提高治疗效果 Objective To investigate the relationship between different dosimetric methods and the cure rate and the postoperative complication of 1 31 Ⅰ treatment of Graves disease. Methods When calculating the 1 31 Ⅰ required for the treatment of Graves’ disease, two different methods were used respectively to observe the cure rate and the complication of the two methods and to make multi-factor comparative analysis. Results The treatment group than the control group, a cure rate increased by about 12%, the recent continuation of hypothyroidism as a permanent hypothyroidism were also significantly reduced, the treatment was significantly better than the latter. Conclusion 1 31 Ⅰ dose calculation, both the formula must be standardized, but also have the flexibility to adjust according to the specific circumstances, can significantly improve the treatment effect