氟以化合物形式广泛分布于自然界，与人类生产、生活和健康的关系十分密切。在氟与健康关系的研究领域中，学者们对氟的有利和有害的生物学作用进行了大量的实验研究，临床观察和流行病学调查，虽获得了许多有价值的结果，但迄今仍存在着三大争论热点，即氟的防龋作用、氟对骨 Fluorine is widely distributed in nature as a compound and has a close relationship with human production, life, and health. In the field of research on the relationship between fluorine and health, scholars have conducted a large number of experimental studies on the beneficial and harmful biological effects of fluorine. Although clinical observations and epidemiological investigations have obtained many valuable results, they still exist. There are three major controversies, namely the role of fluoride in preventing fleas and fluoride in bone.