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目的 研究药用植物清风藤Sinomenium acutum的化学成分.方法 清风藤分离除去青藤碱后的苯母液经过反复硅胶柱色谱,以氯仿、氯仿-甲醇、石油醚-丙酮洗脱分离其中残余的其他生物碱类成分,通过波谱分析方法 和X-射线衍射分析法确定化合物结构.结果 从清风藤除去青藤碱后的母液中分离出4个微量生物碱,分别鉴定为:四氢表小檗碱tetrahydroepiberberine(Ⅰ)、紫堇碱cheilanthifoline(Ⅱ)、8-氧四氢小檗碱8-oxo-canadine(Ⅲ)、8-氧四氢巴马丁8-oxotetrahydropalmatine(Ⅳ).结论 化合物Ⅱ～Ⅳ为首次从该植物中分离得到.“,”Aim To study the chemical constituents of Sinomenium acutum. Methods The mother liquid benzene, after the extraction of sinomenine from Sinomenium acutum, was subjected to re-peated chromatography on a silica gel column and eluted with CHCl3, CHCl3/CH3OH and petroleum ether/acetone. All the isolated compounds were identified on the basis of spectral analy-sis and X-ray diffraction analysis. Results Four compounds were obtained and their structures were cha-racterized as tetrahydroepiberberine (Ⅰ), cheilanthifoline (Ⅱ), 8-oxocanadine (Ⅲ), 8-oxote-trahydropalmatine(Ⅳ), respectively. Conclusion Compounds Ⅱ - Ⅳ were isolated from Sinome-nium acutum for the first time.