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用56只Wistar大鼠,以辐射热甩尾法的甩尾潜伏期作为痛阈,观察伏核微量注入精氨酸加压素(AVP)或抗AVP血清(AAVPS)对痛阈及电针镇痛的影响。伏核内微量注入AVP(0.015单位)既可提高痛阈又可增强电针镇痛效应,1、2和3伏电针的平均针效与对照组比增加了33%(P<0.01),停针后且有40min的后效。AAVPS(1μl)注入伏核消除了内源性AVP的作用后,痛阈明显降低且减弱了电针镇痛作用,1伏的针效与对照组比较减弱了15%、2、3V的针效削弱了32%(P<0.01)。结果提示:脑内内源性的AVP可通过伏核途径调制痛敏感性和电针镇痛效应。
Fifty-six Wistar rats were used as the pain threshold in the tail-flick latency of the radiant heat flick method, and the pain threshold and electroacupuncture analgesia were observed by micro-injection of arginine vasopressin (AVP) or anti-AVP serum (AAVPS) Impact. Microinjection of AVP (0.015 unit) into the nucleus accumbens can both increase the pain threshold and enhance the analgesic effect of electroacupuncture. The average acupuncture efficacy of electroacupuncture at 1, 2 and 3 volts increased by 33% compared with the control group (P <0.01) ), After stopping the needle and 40min after the effect. AAVPS (1μl) injected into the nucleus accumbens to eliminate the role of endogenous AVP, pain threshold was significantly reduced and attenuated the role of electroacupuncture analgesia, 1-volt acupuncture compared with the control group weakened 15%, 2,3V acupuncture effect Weakened by 32% (P <0.01). The results suggest that endogenous AVP in the brain modulates pain sensitivity and electroacupuncture analgesia via the nucleus accumbens.