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目的 探索乙型肝炎 (乙肝 )疫苗 2针法的免疫效果。方法 在河北正定县选择某乡 7个村为试验现场 ,进行了 14年观察。筛选 1～ 7岁HBV易感儿童 2 6 1名 ,按 0、3月免疫程序接种 2针 10 μg乙肝血源疫苗 ,全程免疫后 1、2、3、4、5、6、8、10和 14年对观察人群采集血清标本 ,检测HBsAg、抗 -HBs和抗 -HBc。 结果 抗 -HBs阳性率随免疫年限延长逐渐下降 ,由免疫后第 1年的 93 5 7%降为免疫后 14年的 5 2 13%,在观察期间 ,只检测到 1例HBsAg阳转者 ,并形成了慢性携带状态。结论 2针免疫法与 3针免疫法的免疫效果无差别 ,在某些贫穷和交通不太方便的地区二针免疫法有推广价值。
Objective To explore the immune effect of hepatitis B (HB) vaccine 2-acupuncture. Methods Seven villages in a certain village of Zhengding County, Hebei Province were chosen as the experimental site for 14 years. Two to six children with HBV susceptibility to 1 to 7 years old were screened. According to the immunization schedule of 0 and 3 months, 2 doses of 10 μg HepG2 vaccine were inoculated, 1, 2, 3, 4, 5, Serum samples were collected from the observed population for 14 years to detect HBsAg, anti-HBs and anti-HBc. Results The positive rate of anti-HBs decreased gradually with the prolongation of immunization time, from 93 57% in the first year after immunization to 52.13% in 14 years after immunization. During the observation period, only one HBsAg positive person was detected, And formed a chronic carrying status. Conclusions There is no difference between the 2-needle immunization and the 3-needle immunization. The two-dose immunization in some areas with poor poverty and poor accessibility is worth promoting.