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目的：探讨ＡＮＦ、ＡⅡ在高血压形成和发展中的作用和意义以及局部脑缺血后对其两者的影响。方法：用尾筒法测ＳＨＲ血压，ＲＩＡ测定ＡＮＦ、ＡⅡ水平并与同龄Ｗｉｓｔａｒ大鼠对比，并用ＴＴＣ染色结合图像分析测定局部脑缺血后梗塞灶大小．结果：３、５和７个月龄ＳＨＲ下丘脑ＡＮＦ水平均明显低于同龄Ｗｉｓｔａｒ大鼠，ＡⅡ水平明显升高。在血浆中，ＡⅡ水平无何差异，ＡＮＦ明显高于同龄Ｗｉｓｔａｒ大鼠。局部脑缺血后，ＳＨＲ梗塞灶较Ｗｉｓｔａｒ大鼠的略大，ＡＮＦ、ＡⅡ水平显著增加。结论：中枢较低水平的ＡＮＦ和较高水平的ＡⅡ参与了ＳＨＲ高血压的形成和发展。
Objective: To investigate the role and significance of ANF and AⅡ in the formation and development of hypertension and their effects on both after focal cerebral ischemia. Methods: The SHR blood pressure was measured by the tailgating method. The levels of ANF and AⅡ were determined by RIA and compared with Wistar rats of the same age. The infarct size after focal cerebral ischemia was measured by TTC staining and image analysis. Results: ANF levels in the hypothalamus of SHR at 3, 5 and 7 months were significantly lower than those in Wistar rats at the same age, and the level of AⅡ was significantly increased. In plasma, AⅡ level no difference, ANF was significantly higher than Wistar rats of the same age. After focal cerebral ischemia, SHR infarct size slightly larger than Wistar rats, ANF, A Ⅱ levels increased significantly. Conclusions: Lower central ANF and higher level AⅡ are involved in the formation and development of SHR.